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10.1371/journal.pone.0063903 139 RibeiroA

A local chemical insult can sometimes stop behaving like a local problem

doi: 10.1002/btm2.10360 49 DelilaL.NebieO.LeN

This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gutbrain axis (Joo et al., 2023)