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Authors Contribution Conceptualization, data handling, data analysis, provision of study materials and equipment: HY

This library-independent dDIA strategy also worked well with twofold increase in precursors matched and 75% increase in phosphopeptides (Fig

4.4 Huntingtons disease 4.4.1 Pathogenesis of HD Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline and psychiatric disturbances, which typically manifests in mid-adulthood with an average age of 3050 years old (Ling et al., 2025

Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, Lotze MT, Zeh HJ 3rd, Kang R, Kroemer G, Tang D