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Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers (50, 51) and sorafenib (52)

Somoza, J

PMID: 32716006 Fish Physiol Biochem2023 Feb;49(1):61-74

[DOI] [PubMed] [Google Scholar] 26.Kherrour W., Kalicanin D., Bri L

Retatrutides profile appears different based on available evidence