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however, the putative effect of anti-hormone antibodies on T4 levels remains to be determined [86]

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The increase in circulating homocysteine related to impaired homocysteine metabolism may favor the accretion of a pro-oxidant environment by increasing concentrations of free radicals, by maintaining metal ions in their reduced state suitable for the Fenton reaction, and by changing the redox status of intra- and extracellular thiol groups and, hence, the intracellular redox potential (Mansoor et al, 1993a