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Resistance to apoptosis may partly explain the high levels of intrinsic and acquired resistance to chemotherapy observed in HR-NB, because the treatment protocols and chemotherapeutic agents commonly used to treat NB are meant to trigger apoptotic cell death 6

The innate immune system consists of physical barriers such as the skin, chemical and microbiological barriers in the mucous membranes, phagocytic cells, and soluble factors [29]

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In case of organic disease, that affects the terminal ileum (e.g., Crohn's disease, ileal resection, etc.), bile acids are not absorbed and enter the colon, where they induce diarrhea