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With other types of cancers (many sarcomas, carcinomas, etc.) surgery is the first line of therapy and chemotherapy may be used if after surgery the disease is still present microscopically at the surgical site or the cancer is determined to be at high risk for spread (e.g

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Similarly, the extent to which mitochondrial ultrastructural damage is a cause or consequence of energetic failure remains unresolved ( Looking forward, future research should prioritize large-scale, longitudinal studies that incorporate multi-omics profiling (transcriptomics, metabolomics, and imaging) to define patient-specific metabolic signatures ( 5 Therapeutic strategies targeting mitochondrial and fatty acid metabolism Pharmacological agents, natural products, traditional herbal formulations, gene and cell therapies, and lifestyle interventions have all been explored for their ability to restore mitochondrial function, optimize FAO, and improve cardiac energy homeostasis