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Proc Natl Acad Sci 108:1644616450 Georges F, Le Moine C, Aston-Jones G (2006) No effect of morphine on ventral tegmental dopamine neurons during withdrawal

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Yes, gradually over several weeks to months, maintaining results requires ongoing use or periodic cycles

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Multiple studies have shown that PDEVs derived from diverse botanical sources can attenuate this pathway at different regulatory nodes

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