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Cycling Considerations While Selank does not appear to cause tolerance in the traditional pharmacological sense, cycling remains common practice

Selank ability to modulate HPA axis function while simultaneously normalizing cytokine production offers a dual mechanism that addresses both the trigger (stress) and the response (immune dysregulation)

Aust N Z J Psychiatry 2021;55:196-206

The German BfArM and equivalent agencies (ANSM in France, AEMPS in Spain, AIFA in Italy, URPL in Poland) treat unauthorized human use of these compounds as outside the scope of the marketing authorization regime entirely

Induction is problematic in drug development and an undesirable characteristic for a drug, thus drugs that have Phase II metabolism as their primary route of elimination may be easier to develop