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Prolonged BCL treatment in UC mice significantly reduces colonic FcRn levels, serum ANCA titers, neutrophil-activating peptide (NAP) expression, and inflammatory markers (including TNF-, IL-1, and CRP), while improving disease activity indices and histological scores, outperforming sulfasalazine (73)

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The classic example is lenalidomide, which remodels the substrate-binding surface of the CRBN E3 ligase, enabling selective recognition and degradation of the transcription factors IKZF1 and IKZF3 (233)

The glutathione system comprises the enzymes that synthesize glutathione within a cell as well as dedicated enzymes that use glutathione (GSH) as the means to exert antioxidant effects