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3.3.1 Estrogen maintains mitochondrial health via the PGC-1 signaling axis, inhibiting ferroptosis One of the core mechanisms of estrogens protective effect on mitochondria is through the activation of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1), a master regulator of mitochondrial biogenesis

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Oxidative stress, energy metabolism disorders, and inflammatory responses that occur during this process cause severe damage to myocardial cells

Clean the injection site with an alcohol swab, pinch a fold of skin, insert the needle at a 45-degree angle, inject slowly, and hold for a few seconds before withdrawing