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Notably, epithelial-enriched cancer cells (Supplemental Fig

However, GPX4 is not the only ferroptosis defense

Similar patterns occur with nickel or cadmium exposure, which enhances ferritin degradation through NCOA4-mediated ferritinophagy and activates ferroptosis as indicated by the occurrence of iron accumulation, lipid peroxidation and impairment of the antioxidant system

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Resveratrol treatment also inhibits the intracellular growth of Mtb via the activation of host sirtuin 1 in mouse peritoneal macrophages (148) ( Table 2 )