The addition of cell protein extracts from Fh1-deficient cells did not increase and, heat inactivation did not decrease the production of succinicGSH, indicating that the formation of the compound under these conditions is non-enzymatic
Neutrophils and macrophages produce nitric oxide (NO) and reactive nitrogen intermediates (RNI) that can also contribute to conidial killing
Les voies molculaires documentes en recherche prclinique incluent : (1) activation de la synthse d'oxyde nitrique (NO) via la voie L-arginine/eNOS, (2) surexpression transcriptionnelle de VEGF-A et FGF-2 favorisant l'angiogense, (3) modulation du facteur de transcription prcoce Egr-1 impliqu dans la prolifration fibroblastique, (4) interaction avec les rcepteurs 5-HT2A et dopaminergiques dans certains modles comportementaux, (5) stabilisation de la fonction endothliale via modulation de la eNOS et rduction du stress oxydatif (8-OH-dG, MDA)
New York: Marcel Decker Inc
Compared with the wild-type enzyme, Alda-1 demonstrates superior ability to activate dehydrogenase activity of the ALDH2 2*2 variant, an inactive mutated form of ALDH2 found in ~40% of the East Asian population (133)
