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Panacinar emphysema, which extends throughout the acinus, is the characteristic lesion seen in alpha-1 antitrypsin deficiency and involves dilatation and destruction of the alveolar ducts and sacs as well as the respiratory bronchioles

Developing countries bear the brunt of blindness caused by cataract, due to higher incidence, lower age at onset, and less access to eye care compared to developed countries

Its synchronization of circadian rhythms further restores hormonal timing across the HPO axis, tempering aberrant LH surges and cortisol dysregulation (215)