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In women, estrogen deficiency, including that occurring after menopause, significantly alters GPER expression, impairing WAT metabolic function and increasing the risk of obesity [10]

Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5 + intestinal stem cells

Wu J, Hocevar M, Bie B, Foss JF, Naguib M

doi: 10.1038/cgt.2013.47

Because BPC-157 lacks robust human safety data across the proposed routes of administration, the FDA states it does not have enough information to know whether compounded BPC-157 would cause harm in humans