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148,157,158 Specifically, some cancer cells, such as PDAC and CRC cells, depend on a noncanonical glutamine metabolism pathway in the cytosol under the regulation of oncogenic KRAS activation

However, the high-iron diets or depletion of GPX4 promotes Hydroxyguanosine 8 (8-OHG) release and thus activates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltration and activation during Kras-driven PDAC in mice ( An emerging oncoprotein, Myoferlin, controls mitochondria structure and respiratory functions, has been associated with a low survival in several cancer types including PDAC

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