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In addition, esculetin (25 mg/kg) decreases immobility time and climbing time in the forced swim task elicited in acute restraint stress-induced rats by restoring the activities of antioxidant enzymes including CAT, SOD, GPx and GSH, and reducing the levels of GSSG in rat cortical areas (44)

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From his clinical trial featured in the New England Journal of Medicine , doing so has been shown to reduce new fibroid formation for women who do not yet have fibroids but are considered high-risk AND women who previously underwent a UFE or myomectomy procedure and wish to prevent further disease progression