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In some embodiments, the otoprotectant is any one of the following compounds: In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (I): In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (II): wherein ring A is optionally attached and is a 5-7 membered ring that is aromatic or non-aromatic and can contain one more heteroatoms (N, O, or S atoms)

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Recognition index was calculated by dividing the time spent by animals in exploring known objects from the time spent in exploring novel object and presented as a percentage

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From there the voluntary muscle activity was recorded from the most caudal pair of electrodes, followed by measurement and recording of the average motor unit potential (UMP) and the compound motor action potential (CMAP)