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In contrast to the placebo-treated subjects who experienced minimal changes in body weight over the 16-week treatment period, the pramlintide-treated subjects attained significant weight loss from baseline as early as week 2, which was progressive up to week 16, with no evidence of a plateau

Wang Z, Li Y, Sarkar FH

Kayser-Fleischer Rings: A hallmark sign of Wilson's disease is the presence of Kayser-Fleischer rings copper deposits around the cornea visible during slit-lamp eye examination