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10.3389/fcell.2022.1011435 13

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It is mandatory to acknowledge the limitations and biases of the present work

In addition, previous studies have found in different biological settings including Vhl -deficient renal cancer cells that HIF1 induces the expression of the basic-helix-loop-helix transcription factor Dec1 (Stra13/Bhlhe40) (Ivanova et al., 2001