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Meanwhile, the down-regulation or slight repression of HSPs was observed, including hsp-16.1 (0.0011.16 fold), hsp-16.2 (0.020.19 fold), and hsp-16.48 (0.131.07 fold)

This is because the pH of many of these stringent washes are quite extreme, so you want to reestablish a more neutral pH

alone or co-administered with SERT, it mitigated DEX-induced alteration in acetylcholinesterase activity

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Studies have shown that the penetration speed of these nanocarriers was faster than the rate of carrier clearance by the joint space [70, 71]