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Description

Conclusion AT dysfunction disrupts metabolic homeostasis through complex interactions of cellular stress, inflammatory processes, and regulatory mechanisms

Ym1, Chitinase-Like Protein 3

Taking together, our study demonstrates that MANF inhibits the membrane translocation of CK19 to enhance the cytosolic interaction of CK19 and NICD2, and subsequently accelerates Notch2 signaling activation, which contributes to hepatocyte lineage reprogramming to ICC cells