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Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

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10.1038/nm.4232 10 DorofeyevaN

These preliminary observations are encouraging and may warrant further investigation into use of Omomyc to treat endometriosis and its associated symptomology using three-dimensional in vitro cell culture models and in vivo mouse models of experimental endometriosis routinely employed in our laboratory ( FIGURE 2 6 Potential c-MYC signaling pathways common to endometrial cancer and endometriosis To interrogate potential down-stream pathways relevant to c-MYC signaling in the pathogenesis of endometriosis, we generated a list of c-MYC targets which have been reported in cancer (Zeller et al., 2003) and endometrial adenocarcinoma