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GPX3 is a selenoprotein, and its translation is highly sensitive to the level of selenium (Yan et al., 2013)

This isnt a reason to stop supplementing, but rather to stick to recommended doses rather than taking more than needed

Science 5296 : 9094 Liu Y and Min W (2002) Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner

Water is used instead of phosphate-buffered saline (PBS), because while PBS has comparable osmolarity and buffering capacity to plasma, it also contains salts and other components that could potentially interfere with the detection and quantification of metabolites

Its the number one cause of contact allergy to cosmetics