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DNA is also a major target, with ROS causing strand breaks and base modifications such as 8-hydroxydeoxyguanosine (8-OHdG), leading to genomic instability and activation of pro-apoptotic pathways [46]

Another protease, ALV003, is further along in development and appears to have greater therapeutic potential

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As a potent MMP-9 inhibitor, sulforaphane has been shown to reduce MMP-9 expression levels in cerebral ischemia and encephalomyelitis, thereby attenuating neuroinflammation and promoting blood-brain barrier repair [44, 45]