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Response: We appreciate and acknowledge these comments related to the implementation of the transfer of care modifiers proposal

General oxidative stress models: Across multiple experimental models of kidney injury (ischemia-reperfusion, toxin exposure, aging), higher tissue glutathione consistently correlates with less renal damage, and depletion consistently correlates with more

(2) adoption of the Hospital HarmAcute Kidney Injury eCQM Hospital HarmPressure Injury eCQM beginning with the CY 2025 reporting period

One aspect of the invention pertains to small molecule quinoline derived cations of Formula I, wherein: R 1 is C 1-4 alkyl

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