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doi: 10.1016/j.biopha.2023.116112 123 ZhangSZhangSWangHChenY

Hendershot, Wolfgang Blenau, Reinhard Predel, Paul R

This activity may lead macrophages to engulf large amounts of fat, forming macrophage foam cells and subsequent atherosclerosis (7)

These negative regulatory mechanisms limit the pro-inflammatory effects of IL-6 under normal physiological conditions but may be disrupted in chronic neuroinflammatory states, leading to a sustained inflammatory response (166, 167)