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Alternative buffering agents or careful titration of bicarbonate should therefore be considered, reserving therapy for situations where severe, life-threatening acidemia outweighs theoretical risks

After being injected through the tails of ICR (CD-1) mice, the NP showed significant antinociceptive effects which means loperamide was able to be transported across BBB

Supplementary table

Ozaki et al., 2018), and NQO1 ( CBS, CSE , and NQO1 mRNA levels (Figure 4)

Conato C, Gavioli R, Guerrini R, Kozlowski H, Mlynarz P, Pasti C, Pulidori F, Remelli M (2001) Copper complexes of glycyl-histidyl-lysine and two of its synthetic analogues:chemical behavior and biological activity