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The activated NLRP3 inflammasome not only maintains myocardial interstitial inflammatory infiltration, but its induced proinflammatory factors, such as interleukin (IL)-18 and IL-1, also activate profibrotic growth factors and promote the deposition of collagen and development of a profibrotic population of fibroblasts (46)

There was no significant difference between the effect observed with probenecid or l-carnitine treatment

Specifically, mTORC1 stimulates the expression of glycolytic enzymes by upregulating HIF-1 through the transcription factor Forkhead box K1, thereby promoting glycolysis rather than OXPHOS