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The methanol extract of ADB (1 mg mL 1 ) resisted PHE (1 M)-/K + (60 mM)-induced contractions in aortic rings but not caffeine (opener of ryanodine-sensitive receptors) in a Ca 2+ -free context (Lee et al., 2015)

Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways

1.1 Pharmacokinetics govern pharmacodynamics Dietary phenolic compounds are no drugs and therefore, the term pharmaco-kinetics is strictly speaking not precise, but frequently used in the context of natural plant-derived compounds