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Graphic Abstract Access this article Similar content being viewed by others Abbreviations MAO: Monoamine oxidase PD: Parkinsons disease DA: Dopamine FDA: The food and Drug Administration TH: Tyrosine hydroxylase AADC: Aromatic amino acid decarboxylase DOPAC: 3,4-Dihydroxy phenylacetic acid HMV: Homovanillic acid DDC: Dopa decarboxylase DAT: Dopamine transporter COMT: Catechol-O-methyl transferase FAD: Flavin adenine dinucleotide MAOIs: MAO inhibitors SAR: Structureactivity relationship BHT: Butylated hydroxytoluene EWG: Electron-withdrawing group EDG: Electron donating group BBB: Blood Brain Barrier CNS: Central nervous system References Ball N, Teo W-P, Chandra S, Chapman J (2019) Parkinsons disease and the environment

2020 May-Jun, Volume 25 (Issue 3), Pages 1361-1367

3.2.1 Steroidogenic enzyme inhibition 3.2.1.1 17-hydroxysteroid dehydrogenase (HSD17B) suppression Cadmium exposure directly inhibits HSD17B enzymatic activity with an IC50 of 2.2 M, resulting in an 85% reduction in testosterone synthesis capacity

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