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Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis

Thus the best-known "function" of B 12 (that which is involved with DNA synthesis, cell division, and anemia) is a facultative function that is mediated by B 12 -conservation of an active form of folate which is needed for efficient DNA production

Its an incredibly effective preservative, but its efficacy isn't infinite, and it's certainly not invincible

However, when it is absent, as in Piezo1 KO embryos, the level of cholesterol synthesis in the CNS and the levels of neutral lipids and cholesterol in NSCs are reduced (Nourse et al., 2022)

Subtracting this 0.5 g of reabsorbed B12 from the 1.5 g that normalizes blood parameters results in a requirement of 1.0 g absorbed per day (for those without pernicious anemia)