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Given the anatomical reality that the brainstem comprises many densely-packed but functionally-heterogeneous nuclei, any small errors in spatial registration caused by failure to use brainstem-specific registration are highly likely to lead to decreased sensitivity in signal and type 2 errors ( Furthermore, the brainstem is especially prone to physiologically-driven movement artifact given that it pulses with every heartbeat [e.g., ( A large majority of neuroimaging studies in ME/CFS have not used brainstem-specific spatial co-registration, normalization, or physiologically-derived movement artifact regression techniques

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Mitesh Joshi, NMIMS Sunandan Divatia School of Science for providing help with figure artwork

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