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Because pK a is a log 10 scale, a 1.0 unit change in pH on either side of the pK a will be associated with a tenfold change in the ratio of the associated and dissociated species, and a 2.0 unit change in pH on either side of the pK a will be associated with a 100-fold change in the ratio

We downloaded correlation summary statistical data for this analysis from the GWAS Catalog 50

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One big advantage is the ability to select between IPB and ALL-I compression, as opposed to just the one compression type on the Mark II