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Chronic intake above 200 mg daily has been associated with sensory neuropathy, characterized by numbness, tingling, and loss of sensation in the hands and feet

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Furthermore, the expression of both iNOS and COX-2 is increased by activated NF-B

He retired in 2011

Neuroscience 392:241-51 2018 PMC6204308 Khan AM, Grant AH, Martinez A, Burns G, Thatcher BS, Anekonda VT, Thompson BW, Roberts ZS, Moralejo DH, Blevins JE