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Sci Rep 8(1):7276 Wagner V, Gil J (2020) Senescence as a therapeutically relevant response to CDK4/6 inhibitors

To adapt to harsh environments, PDAC cells rely on lysosomes for nutrient degradation and regeneration, such as through macropinocytosis [151] and autophagy [152], to obtain sufficient fuel for survival [153, 154]

In bovine subcutaneous adipocytes, GA reduced TG levels b increasing the expression of lipolysis-related genes such as ATGL and HSL, and activating the metabolic regulator AMPK (Jin et al., 2022)

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Several studies have shown that SDH-deficient cells exhibit increased tumorigenesis and that this increase is reversed by the addition of -KG, supporting the idea that succinate accumulation contributes to tumorigenesis through epigenetic modification 100