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Several preclinical and clinical studies have demonstrated that CSF1R inhibitors, including small-molecule tyrosine kinase inhibitors (e.g., PLX3397, GW2580, and Ki20227) and monoclonal antibodies targeting CSF1R or its ligand CSF1, can effectively deplete or reprogram TAMs, thereby improving tumor immune contexture and enhancing the efficacy of ICIs (161)

A relevant platform needs to be developed to achieve big data integration and efficient use of experimental data, reliable age biomarkers should also be optimized, a perfect system for the assessment of biological aging should be established, personalized interventions should be emphasized, and precise interventions should be advocated

The GST tag enhances the solubility and stability of the target protein, which is crucial for obtaining high-quality crystals for X-ray diffraction studies or for preparing concentrated samples for NMR analysis

Thompson, H., Rybalka, A., Moazzez, R., Dewhirst, F

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