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This selectivity is of high interest to researchers, as MC1R is primarily responsible for stimulating melanin production (melanogenesis) in skin melanocytes

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For most procedures carried out under local anaesthetic, you can eat and drink normally beforehand and drive yourself home afterwards, though many patients prefer to bring someone with them for support

It is also dependent on acquired factors such as ultraviolet light (UVL), the presence of inflammation (particularly that involving basal layer damage), and some types of infection (notably HPV infection in the genital and perigenital areas)