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In a study of patients with end stage renal impairment, mean elimination half-life was prolonged in uremic patients due to increased volume of distribution and reduced clearance

Niaz, E

Karlmark KR, Wasmuth HE, Trautwein C, Tacke F (2008) Chemokine-directed immune cell infiltration in acute and chronic liver disease

CD8 + T cells deficient in LXR produce significantly more effector cytokines (such as IFN) than do their wild-type counterparts during recall responses [30]