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Emerging human studies provide encouraging translational support, showing that luteolin, administered primarily as ultramicronized PEA-luteolin, reduces key inflammatory cytokines (IL-6, IL-1, TNF-), mast-cell mediators, and oxidative stress biomarkers ( Therefore, this review aims to synthesize current mechanistic, preclinical, and translational evidence on luteolin across major female reproductive disorders and to evaluate its potential as a multi-target therapeutic candidate

Environmental factors such as cold weather, low humidity, harsh soaps, and frequent washing can exacerbate dryness

However, the scientific evidence is not yet conclusive, meaning that many of the promised effects have not yet been clearly proven

tabacum cell suspension to elevated temperature (55C) also resulted in increased GR activity (Locatto et al., 2009)

showed that intracellular glutamate accumulation following cyst(e)ine depletion or system x C - inhibition is a key contributor to the induction of ferroptosis, and glutamate toxicity can be alleviated by converting excess glutamate to -glutamyl-di- or tripeptides via promiscuous enzymatic activities of glutamate-cysteine ligase catalytic subunit (GCLC) 12