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doi: 10.1523/JNEUROSCI.3878-11.2011

Accordingly, NP design and experimental studies should explicitly balance benefits against risks to maximize clinical effectiveness while prioritizing patient safety

In addition to the response to infection, tissue damage itself can initiate inflammation, through the release of damage-associated molecules including arachadonic acid metabolites, free extracellular matrix molecules, nucleotides and others (Van Crombruggen et al., 2013)