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Ther Adv Chronic Dis

Autophagy exhibits dual effects in most diseases, and identifying the effects of autophagy in pathological tissues is a prerequisite for targeted autophagy-based therapy

Secondly, we detected the axonal-specific protein 3-tubulin and observed that, similar to neuronal markers, PPARa over-expression partially suppressed the reduction of 3-tubulin in the injured area and preserved 3-tubulin levels

Apr 25 2000;54(8):1698-700

Rather than serving merely as a chronological marker, aging drives a series of interconnected molecular and cellular alterations that create a permissive environment for AD pathology