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In addition, most of the effective analgesics in NP failed to provide symptomatic relief of CIPN and often exhibit side effects (Han and Smith, In general, unlike other types of NP (including those induced by trauma and diabetes) axonal degeneration in peripheral nerves is not present in CIPN (Ji et al., Regarding to CIPN induced by the taxanes, Duggett et al

Reduced ventilation due to loss of elastic recoil in the emphysematous lung, together with the loss of the capillary bed and the generalized inhomogeneity of ventilation due to the patchy nature of these changes, leads to areas of V A /Q mismatching that result in arterial hypoxemia

Jpn J Cancer Res , 92:328336, 2001

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VDAC1 transferred via EVs induces PTX resistance siRNAs were used to silence the expression of VDAC1 protein in GC cells to further investigate the potential role of EV-derived VDAC1 protein in mediating intercellular drug resistance transmission