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In the prefrontal cortex, 5-HT2A hypermethylation demonstrated a bidirectional regulatory effect, influencing treatment efficacy while also being modulated by medication (Abdolmaleky et al., 2006)

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Furthermore, elevated levels of reactive oxygen species (ROS) that provoke oxidative stress and lipid peroxidation affect the fluidity, stability, and integrity of membranes, resulting in cell death following the interaction with NPs [192]