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Compound 55, having a vardenafil core, was the most potent dual PDE5/class I HDAC inhibitor [263]

2016;150(2):367-79.e1

GSTs are multifunctional enzymes that catalyze the conjugation of glutathione (GSH) to electrophilic compounds, including xenobiotics and reactive oxygen species (ROS), converting these into less toxic metabolites for excretion 49

Abstract The incidence of neurological disorders, particularly age-related neurodegenerative pathologies, exhibits an alarming upward trend, while current pharmacological interventions seldom achieve curative outcomes

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