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146152 Similarly, LGR5, a critical component of the Wnt/-catenin signaling pathway, plays a pivotal role in sustaining stemness and enhancing tumor growth

Therefore GLP-1 RAs are more strongly supported by the available data on human PCOS as metabolic and weight-lowering agents than as weight-independent anti-inflammatory treatments

ROS generation in the context of antioxidants is necessary for spermatogenic processes to occur

Zeisberg et al., 2008), which appears to be a key process leading to glomerular sclerosis in DKD (Kizu et al., 2009), is also a significant element engaged in heart and kidney fibrosis