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simultaneously, it silences effector genes (e.g., perforin) through methylation, increasing promoter methylation levels by 40% and resulting in a 60% downregulation of expression (115, 116)

Fix: Start with 2030 mcg/day and assess tolerance over 12 weeks

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[DOI] [PubMed] [Google Scholar] 81.Roman-Blas J.A., Contreras-Blasco M.A., Largo R., lvarez-Soria M.A., Castaeda S., Herrero-Beaumont G