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Eichner, D (Jan 2015)

Not FDA-Approved: This product has not received FDA approval as safe and effective, but federal law restricts it to prescription veterinary use only

Understanding the distinct mechanisms and indications of each treatment is essential when considering their use together, particularly as Mounjaro's effects on appetite and food intake may impact overall nutritional status

What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect