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"But IgG antibodies never cross the cell layers and they can never make it inside the cysts." This limitation is crucial, he added, because the interior of each cyst -- essentially a sealed chamber lined with epithelial cells -- is the location where disease-driving activity occurs

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Clinical tolerability data In the Beck et al

However, managing patients with IPF and CKD is challenging because information on the effectiveness and safety of antifibrotics in those patients is lacking due to the absence of specific clinical trials