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reported an investigation from Germany that utilized a randomized, placebo-controlled, triple-blind trial using confocal laser scanning microscopy to determine the cosmetic effects and tolerance of a commercial drinkable collagen supplement (2.5 g with vitamins C and E plus minerals [zinc and biotin]) for 12 weeks in 60 female participants 4070 years of age [32]

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However, only ~ 50% patients with opioid-induced constipation exhibit satisfactory response to PAMORA-based clinical management strategies targeting MORs in the enteric nervous system, and we observed that naloxegol could only partially alleviate morphine-induced constipation