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However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH

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Mouse hippocampal neurons stained by Nissl staining showed that the hippocampal neurons of mice in the Con, H1d, and H3d groups had an orderly arrangement but a disordered arrangement after prolonged hypoxia, especially in the H14d group

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